Take the exit on the highway (Autostrada A1) Valdichiana-Bettolle( n.28 ), follow the signs for Montepulciano. Once in Montepulciano and specifically at the Saint Agnese roundabout, continue straight on for about 300 mt. (328 yd.); once you crossover the small bridge where on your right you will find the ACI auto breakdown service; turn right and from here continue straight on for the Historical Center (centro storico) where you will reach Piazza Grande.

Take the exit on the highway (Autostrada A1) Chiusi-Chianciano Terme (n.29); follow the signs for Chianciano, then for Montepulciano. You then arrive at a fork in the road, where right in front of you will find the Temple of Saint Biagio, there turn right towards Montepulciano, and after about 300 mt. (328 yd.) or so, turn left following the signs for the Historical Center. Turn at your first left, follow the road all the way up until you reach Piazza Grande.